ESTĒE LAUDER'SLONGEVITY SCIENCEIt begins with the power of SIRTUINs,key Longevity proteins, key to uncoverthe power of skin age reversal.WHAT ARE SIRTUINS? SIRTUINS, also known as Longevity Proteins, are proteins in our cells that control a number of functions to help optimize skin cell activity and longevity, such as cell renewal, shape, energy production. Sirtuins help promote cell lifespan, helping them live longer, and healthspan, helping them act younger. SIRTUINS WEAKEN WITH ENVIRONMENTAL STRESS AND AGINGOne of the ways Sirtuins is normally turned on is in response to stresses, such as internal or external stress, regulating various stress responsive pathwaysto alleviate cellular stress and improve cell survival. As people age, Sirtuins become inactivated or “turned off”, and we lose the protection of the cellular protective programs governed by sirtuins. ESTĒE LAUDER IS A PIONEER IN SIRTUIN RESEARCHA remarkable 15-YEAR Longevity Science journey, in partnership with Harvard & MIT scientists, and 20+ scientific conference & publicationsEstée Lauder discovered a major skincare breakthrough - the power to activate Sirtuins to empower skin's visible age reversal. ESTĒE LAUDERSIRTIVITY-LPTM PERFORMANCE-SUSTAINING TECHNOLOGY TO ACTIVATE SIRTUIN ACTIVITYTo support skin to act younger for longer A COMPREHENSIVE GROUPOF LONGEVITY PROTEINACTIVATOR FOR SKIN YOUTHPATENTEDSIRT 1SIRT 2RENEWAL/RECOVERYSTRENGTH/SHAPEGives skin cell thecritical time neededto recover/repairHelps skin cells maintainnatural structure anda more youthful shapePATENTEDSIRT 3SIRT 6ENERGYINTEGRITY/LIFEBoosts skin’s naturalenergy productionExtends skin cells’natural lifeSIRTIVITY-LPTM TECHNOLOGY TURNS ON A NETWORK OF LONGEVITY PROTEINS THAT ACTIVATES SKIN’S SOURCE OF POWER TO LOOK AND ACT YOUNGER, FOR LONGER. “We’re always pushing to develop skincare founded on science, formulated with the proprietary SIRTIVITY-LPTM technologies to achieve our ultimate goal of reawakening your skin’s youthfulness and peak performance”DR. NADINE PERNODETSenior Vice President, Global Research & Development, Skin Biology & Bioactives